Fig. 4. A: 3D Model of CVB3 Protease 2A. B: 3D Model of CVB3 Protease 3C. C: Function of proteases 2A and 3C in the host‐cell. Protease 2A is responsible for the cleavage of elF4G and so suppresses host‐cell translation. Cleavage of DAP5 by CVB3 2A leads to the byproducts DAP5‐N and DAP5‐C, which suppress the transcription of anti‐apoptotic genes and support the transcription of pro‐apoptotic genes. Protease 3C cleaves and activates procaspase 8. Furthermore it supports the expression of Bax. Both effects lead to mitochondrial degradation and cell‐death.